Peripheral Vascular Disease

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What is PVD?

Peripheral vascular disease (PVD) is also called peripheral artery disease (PAD). This is a type of cardiovascular disease that involves a slow and progressive narrowing of the blood vessels (arteries) outside the heart and brain. This means that blood flow can become restricted or completely blocked.

 

While any part of the body that relies on these blood vessels can be affected, PVD most commonly affects the legs and feet.

 

Around 15 per cent of Australians have PVD and incidence increases with age.

What causes PVD?

The most common cause of PVD is atherosclerosis. This is when cholesterol, fat, and other products in the bloodstream such as proteins and calcium build up on the artery walls forming a substance called plaque. Plaque buildup can cause the arteries to become narrow, either restricting or blocking blood flow. Atherosclerosis is often considered to be a heart problem, but it can occur in any of the arteries in your body. Other possible causes of PVD include:

 

·       injury to the arms and legs

·       unusual muscle or ligament anatomy

·       infection.

 

Symptoms

Around half of people with PVD don’t show any symptoms, which means it’s possible to have the condition and not know. 

 

For those who do notice symptoms, they can vary and will depend upon which part of the body is affected by restricted blood flow. The most common symptom is painful cramping in the legs or hips, usually after physical activity such as walking or climbing stairs. Other possible symptoms include:

 

·       weakness or numbness in your leg 

·       pain in your legs even if you’re resting or laying down

·       your lower leg or foot is cold, especially compared to the other side

·       slower hair growth or hair loss on feet and legs

·       slower growing nails or nails that are weak and brittle

·       sores or ulcers that won’t heal

·       a change in the colour of your legs, or skin that turns pale or bluish

·       shiny skin on your legs

·       pain, aching or cramping in your arms when doing manual tasks

·       muscle wasting in your legs

·       weak or no pulse in your legs or feet

·       erectile dysfunction in men.

 

Risk factors

There are several risk factors for PVD, however the most significant is diabetes. Those with type 2 diabetes are three to four times more likely to develop PVD. Smoking is also one of the greatest risk factors for PVD. Other risk factors include:

 

·       age (especially if you’re over 50)

·       a family history of PVD, heart disease or stroke

·       being male

·       being a postmenopausal female

·       high cholesterol

·       high blood pressure

·       being overweight

·       eating a poor diet, especially one high in fat

·       sedentary lifestyle.

Complications of PVD

People with PVD are up to six times more likely to have a heart attack or stroke, compared with those who don’t have it. Reduced blood flow can also increase the risk of limbs developing gangrene (where tissue begins to decay and die). As the only cure for gangrene is amputation, people with PVD are at a higher risk of having a limb amputated.

 

People with diabetes or those who smoke have the highest risk of developing complications from PVD, as diabetes and smoking also contribute to reduced blood flow.

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Diagnosis

PVD is usually diagnosed via a physical examination, taking a detailed medical and family history, and may also involve some other tests. These include:

 

·       Pulse check — This is done as part of the physical examination to check for signs of reduced blood flow through blood vessels.

·       Ankle-brachial index (ABI) — This compares the blood pressure in the ankle with the blood pressure in the arm to check for differences.

·       Exercise test — Blood pressure is taken while you’re on a treadmill to check for a drop in blood pressure in the affected area.

·       Imaging tests — A Doppler ultrasound may be used to check for narrowed sections of blood vessels.

·       Angiogram — For this test, a contrast dye is injected into your blood vessels which shows up on an x-ray. 

 

Treatment

Treatment of PVD aims to control the symptoms of the disease and halt or slow its progression. This is to lower the risk for heart attack, stroke or other complications. Treatment may involve several things including non-surgical and surgical treatments.

 

Non-surgical treatments

 

·       Lifestyle modifications can control risk factors and may include regular exercise, healthy eating and quitting smoking.

·       Medications to:

o   lower LDL (bad cholesterol levels)

o   lower blood pressure

o   prevent blood clots

o   dissolve existing blood clots

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Surgical treatments

Angioplasty — This procedure involves threading a thin tube (catheter) into the narrowed blood vessel, via a small incision, usually in the leg. When the catheter reaches the blockage in the blood vessel, a small balloon inflates from the tip which widens the blood vessel and improves the blood flow. The procedure is done under sedation and a local anaesthetic. 

 

Stent— A stent is a tiny mesh tube that is surgically inserted into a blood vessel to keep it open. This procedure is done during angioplasty.

Atherectomy — This is a keyhole procedure that involves removing the build-up of plaque from the blood vessels.

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Bypass surgery — This is the most serious type of surgery and is usually performed in severe cases that don’t respond to other treatment, or where there are large sections of damaged blood vessels. During this procedure, a section of healthy vein is removed from another part of the body and surgically grafted (attached) to provide a detour around the blocked area. Sometimes a piece of synthetic tubing may be used instead of a healthy vein.

When to seek medical advice

 

Many cases of PVD respond well to non-surgical treatments if diagnosed early.

If you have leg pain, numbness or any of the other symptoms listed above, call your doctor and make an appointment. They are not normal signs of aging.

If you have PVD and you notice your symptoms are getting worse, you should also seek medical advice.

 

References:

Au TB et al; Peripheral arterial disease: Diagnosis and management in general practice; Arteries & Veins; Volume 42, No.6, June 2013 Pages 397-400, https://researchonline.jcu.edu.au/31656/

American Family Physician, Peripheral Vascular Disease: Diagnosis and Treatment, https://www.aafp.org/afp/2006/0601/p1971.html

Australia and New Zealand Society for Vascular Surgeonshttps://www.anzsvs.org.au/

Australian Family Physician, Peripheral arterial disease: Diagnosis and management in general practice, https://www1.racgp.org.au/ajgp/2020/may/peripheral-artery-disease-in-lower-limbs

Better Health Channel, Peripheral vascular disease, https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/peripheral-vascular-disease

Conte SM et al; Peripheral Arterial Disease; Heart Lung & Circulation April 2018 Volume 27, Issue 4, Pages 427–432, https://pubmed.ncbi.nlm.nih.gov/29150158/

healthdirect, Peripheral vascular disease https://www.healthdirect.gov.au/peripheral-vascular-disease

Healthline, Peripheral Vascular Disease, https://www.healthline.com/health/peripheral-vascular-disease

Heart Research Institute, Peripheral artery disease, https://www.hri.org.au/health/learn/cardiovascular-disease/peripheral-artery-disease

John Hopkins Medicine, Peripheral Vascular Disease, https://www.hopkinsmedicine.org/health/conditions-and-diseases/peripheral-vascular-disease

Mayo Clinic, Peripheral artery disease (PAD),https://www.mayoclinic.org/diseases-conditions/peripheral-artery-disease/symptoms-causes/syc-20350557